Dr. Bernard Omolo has authored a paper entitled “A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines,” which is to appear in the next issue of  the journal  Pigment Cell and Melanoma Research.

The paper  describes a method for estimating p53 signaling function in melanomas from a signature of gene expression, obtained through DNA microarray analysis of genes correlated with the G1 checkpoint function. The signature was found to be prognostic for  the development of distant metastasis in melanoma patients. These results therefore suggest that expression profiling of primary melanomas should be clinically useful. Full version of the paper is available online.Omolo teaches in the Division of Mathematics and Computer Science in the College of Arts and Sciences at the University of South Carolina Upstate.